Computational annotation of protein function
نویسندگان
چکیده
منابع مشابه
Computational protein function predictions.
What is the role of this protein? Where does this protein localize in a cell? Are there any ligands that bind to this protein? If so, what are they? Which residues constitute a functional site of the protein? These questions, which in a broader sense seek the biological function of a protein, are fundamental and central in modern biology. Ultimately, the biological function of a protein needs t...
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With the high number of sequences and structures streaming in from genomic projects, there is a need for more powerful and sophisticated annotation tools. Most problematic of the annotation efforts is predicting gene and protein function. Over the past few years there has been considerable progress in automated protein function prediction, using a diverse set of methods. Nevertheless, no single...
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As a result of the genome sequencing and structural genomics initiatives, we have a wealth of protein sequence and structural data. However, only about 1% of these proteins have experimental functional annotations. As a result, computational approaches that can predict protein functions are essential in bridging this widening annotation gap. This article reviews the current approaches of protei...
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15 صفحه اولStructure Based Identification of Protein Family Signatures for Function Annotation
2 Introduction Protein sequences are known to evolve much faster than structures. Pairs of distantly homologous proteins with very low sequence similarity may still share very similar folds and functions. One example of well-preserved structural motifs is given by specific three-dimensional orientations of amino acid residues in the active site of a protein, which are responsible for protein’s ...
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ژورنال
عنوان ژورنال: MOJ Proteomics & Bioinformatics
سال: 2018
ISSN: 2374-6920
DOI: 10.15406/mojpb.2018.07.00233